技術補佐員

山本直美　YAMAMOTO Naomi

 

抱負・コメント

　素晴らしい研究に携われることを嬉しく思います。

研究室が円滑に進むように、積極的に何事も取り組んでいこうと思います。

 

テクニック

細胞培養、組織作成（凍結切片）、免疫染色、Realtime-PCR、Western blotting、ELISA、動物実験

 

これまでに携わった研究

Shimamura M, Hayashi H, Ju N, Yoshida S, Baba S, Sasaki T, Mochizuki H, Morishita R, Nakagami H. R-spondin 3/LGR4 axis is a novel inflammatory and neurite outgrowth signaling system in the ischemic brain in mice. Stroke. in press

 

Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice. Ju N, Hayashi H, Shimamura M, Baba S, Yoshida S, Morishita R, Rakugi H, Nakagami H. Sci Rep. 2022 Jul 21;12(1):12474. doi: 10.1038/s41598-022-16843-7.

 

Ju N, Hayashi H, Shimamura M, Yoshida S, Nakamaru R, Nakagami H, Morishita R, Rakugi H. Prevention of Acute Lung Injury by a Novel CD14-inhibitory Receptor Activator of the NF-кB Ligand Peptide in Mice. ImmunoHorizons. 2021 15;5(6):438-447

 

Shimamura M, Kaikita K, Nakagami H, Kawano T, Ju N, Hayashi H, Nakamaru R, Yoshida S, Sasaki T, Mochizuki H, Tsujita K, Morishita R. Development of anti-thrombotic vaccine against human S100A9 in rhesus monkey. Scientific Reports. 2021 1;11(1):11472

 

Nan Ju, Munehisa Shimamura, Hiroki Hayashi, Yuka Ikeda, Shota Yoshida, Ayumi Nakamura, Ryuichi Morishita, Hiromi Rakugi, Hironori Nakagami. Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis. Sci Rep 2019 Oct 28;9(1):15434.

 

Kawano T, Shimamura M, Nakagami H, Kanki H, Sasaki T, Mochizuki H. Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice. PLOS ONE 2019 May 2;14(5):e0215482. doi: 10.1371/journal.pone.0215482. eCollection 2019

 

Shimamura M, Nakagami H, Shimizu H, Wakayama K, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Mochizuki H, Morishita R. Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice. Biomed Res Int. 2018 Jul 30;2018:4637084. doi: 10.1155/2018/4637084.

 

Shimamura M, Nakagami H, Shimizu H, Mukai H, Watanabe R, Okuzono T, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Ju N, Mochizuki H, Morishita R. Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke. Sci Rep. 2018 Dec 11;8(1):17770. doi: 10.1038/s41598-018-35898-z.

 

Kawano T, Shimamura M, Nakagami H, Iso T, Koriyama H, Takeda S, Baba K, Sasaki T, Sakaguchi M, Morishita R, Mochizuki H. Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice. Hypertension. 2018 Dec;72(6):1355-1364. doi: 10.1161/HYPERTENSIONAHA.118.11316.